Endothelial dysfunction as the typical pathological state

The problems considered in the review are: mechanisms of formation physiological and pathological endothelium phenotypes, involvment hematovascular homeostasis, immune processes, inflammation, systemic inflammatory response. reversibility endothelial dysfunction, participation reaction, etc. are discussed. validity conventional term «endotheliitis» for dysfunction various diseases, including COVID-19 is analysed. We accept that a kind condition having both common features many diseases some depending on dominance particular phenotype (in sepsis, hypovolemic shock, etc.). concept as universal mechanism endogenization generalization process proved. development methods affected remodeling promising area scientific research.